°Bx (Brix) represents the degree of sweetness and level of sugars in consumable products.  At °Bx GLYCEMIC IMPACT℠ ,

a sister company of Glycemic Research Institute®, we focus on the impact on sugars to the body and underlying mechanisms

for optimal health and performance. With over 30 years of experience, we are proud to serve clients with a collaborative and trusted clinical testing certification granting clients an associated proof of integrity Brix-Certified seal upon review and approval.

At, °Bx GLYCEMIC IMPACT℠ , we help clients create and/or re-formulate any edible product by providing independent investigations and verification in order to identify the Blood-Sugar & Metabolic Impact of a Nutraceutical, Pharmaceutical,

Food or Beverage, Sugar, Sweetener &Bio-Sweetener for claims and FDA CFR21 label substantiation.

Having a °Bx GLYCEMIC IMPACT℠ (The Science of Sweetness) Brix-Certified Brix-Certified seal on your product(s) label is proof to your consumers that you care about health, quality and ingredient integrity; a valuable nutritional-impact identification.  As a result, helps you improve market share and consumer loyalty..  

Our team welcomes you to learn more about °Bx GLYCEMIC IMPACT℠, The Science of Sweetness, and instructions how to submit your product(s) for certification! Please click on the button below.

The Science of Sweetness

Glycemic Research Institute®
Human Nutrition & 
Biochemistry Division 
Childhood Obesity Unit
Clinical Trials Laboratory

Certification Seal for
the Latin Market
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Low Glycemic


Quantification of

Protocol Perimeters

Research Designand


Weight Loss Products
Proven Not to Work

L-Carnitine and other
supplements found 
ineffective in fat
burning & weight loss

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Glycemic News

Breaking News

Scientist Discover 
Why Artificial 
and Diet Sodas 
are Fattening

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• American Diabetes Association Recognizes Benefits of The Glycemic Index


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• American Diabetes Association Ties Fruit Juices to Diabetes


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Clinical trials show 
that INULIN increases glycemic response of foods

• Glycemic Research Institute® Publication at USDA Website


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• USDA Reports Low Glycemic Load Diets Trigger Weight Loss


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• U.S.D.A. Announces Project to Develop Low Glycemic Snacks and Low Glycemic Starches 


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• High Glycemic Carbs Associated with Vision Loss


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• 2008 Official Response to the Accord Diabetes Trial


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• Diabetes and Obesity Risk in Children


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• Harvard Medical School Nurses’ Health Study Position on Glycemic Index


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A Professional Clinical Research Organization Specializing In Glycemic Index Testing with over 
30+ Years of Glycemic Expertise

Glycemic Research Laboratories
Specializing in: FDA & FTC
Legal Glycemic Index Claims

(Since 1983) 

Claim Substantiation For:
Foods • Meals • Prepared Foods
Nutraceuticals • Pharmaceuticals
and Products in Development

  • Serving the largest food & research companies in the world

  • Official clinical testing facility for the Glycemic Research Institute®

  • Board approved Human In-Vivo clinical trials

  • Low glycemic index product substantiation

Clinical Trials
Legally Required
for Low Glycemic

"Having a well controlled clinical trial is like having money in the bank"
July 2008 Diabetes Forecast
American Diabetes Association



Click here more information 

For information on

Glycemic Index and  
Glycemic Load Defined,

click following links:

Federal Government Guidelines for Authorized Certification Marks 

  • Client Responsibility

  • Safety Guidelines for Test Food(s) Being Submitted for Clinical Trails

• Glycemic Research Laboratories conducts human In Vivo clinical studies, which is the only legal product claim substantiation accepted by the United States government, including the FDA & FTC.


• Laws in the United States dictate that all glycemic index claims made by food or dietary supplement products require substantiation via human clinical trials (In Vivo). Documentation demonstrating the validity of clinical evidence for said claims is required by the Federal government.


• Glycemic Research Laboratories clinical trials are approved by the appropriate Review Boards, and include diabetics, non-diabetics, overweight, and obese subjects.


• Glycemic Research Laboratories conducts clinical glycemic index testing for clients in the United States, and worldwide.

Glycemic Research Institute®

The following products have been submitted to the Glycemic Research Institute® and Glycemic Research Laboratories for Human In-Vivo Clinical Trials.

This is a short list of products submitted to Glycemic Research Institute® for Board Approved Human In Vivo Clinical Trials.

Click here for more details

Hershey Foods

State of Florida


of Citris




Fresh Meadow Bakery

White Wave

Soy Milk

Burger King


E.D. Smith & Sons Salad Dressing


Mueller's Pasta American Italian Pasta Company


Food for Life Bread, Pasta, Cereal and Waffles

U.S. Mills

Junior's Cheesecake

Featured on QVC

Alvarado Street Bakery

Joseph's Bakery

Gardenia Bakery

Turtle Mountain

Medifast, Inc

Interbake Foods

As Seen On QVC

• Glycemic Research Laboratories has the highest rate of accuracy available, with specific in-real-time analytical testing methods specifically developed by Glycemic Research Laboratories. The typical accuracy of GI testing has a variable of 80 percent. Glycemic Research Laboratories accuracy has a variable of < 2 percent.


• Glycemic Research Laboratories clinical studies include various glycemic index protocols suited to the clients needs, including studies utilizing diabetics, non-diabetics, obese, and overweight subjects. Glycemic Research Laboratories can determine clinically if the product submitted:


  1. Is shunted into and/or stored in adipose tissue fat cells (is fattening)

  2. Exacerbates hypoglycemia, diabetes, and insulin resistant disorders

  3. Is acceptable for diabetics to consume

  4. Over-elevates blood glucose or insulin levels

  5. Affects sports performance in athletes

Internationally Accredited



Glycemic Research Institute®
Human Nutrition & 
Biochemistry Division


Glycemic Index & 
Load Clinical Trials
Obesity Research & Clinical Trials
Diabetes Research & Clinical Trials
Adipose Fat Storage 
Investigations & Trials


Human In Vivo Clinical 
Trials Laboratory
Department of Dietary Supplements 
Department of Foods & Beverages 
Department of Pharmaceuticals 



Glycemic Research Institute®
Human Nutrition & 
Biochemistry Division 
Childhood Obesity Unit
Clinical Investigations &
Trials Laboratory



Glycemic Research Institute®
Sports Physiology Laboratory

Department of Biological Circuitry
Department of Sports Performance

Sports Supplements & 
Sports Drinks
Clinical Investigations & 
Trials Laboratory 



Glycemic Research Institute®
Food Addictions Laboratory 
Department of Neuroscience 

Cephalic Research Unit
Department of Brain 
Glycemic Indexing







The Glycemic Research Institute® is an Internationally Accredited Testing & Certification Organization approved by International Governments, including the United States government. 

The Glycemic Research Institute® Certification Program and Certification Programs are Registered, Authorized, and Licensed by the United States, Canada, and United Kingdom governments, and accepted Worldwide per World Health Organization (WHO) Guidelines.


The Glycemic Research Institute® government-issued Certification Marks represent 25-years of Clinical Research in the fields of the Glycemic Index, Diabetes, Cephalic Response, Obesity, Adipose Tissue Fat-Storage, and Childhood Obesity.


The Glycemic Research Institute® Certification Marks are legally authorized to make a clinical statement, such as “LOW GLYCEMIC” or ‘DIABETIC FRIENDLY” or “LOW CEPHALIC INDEX” or “KID FRIENDLY” or “NATURAL BEVERAGE” on an FDA label for a commercial food, Nutraceutical, beverage, or Pharmaceutical product. 


Any Certification Mark statement representing a clinical claim must be backed by Human In Vivo Clinical Trials per FDA CFR 21 guidelines and per the Clinical Trials Guidelines submitted by the organization licensed to use said Certification Mark.


A Certification Mark on a commercial product legally enables bounding (being under legal obligation) under the following guidelines:


  • The existence of a Legal Product Certification Agreement between the manufacturer of a product and the organization that possesses accreditation by a national government for both testing and product certification.

  • Legal evidence that the product was successfully tested in accordance with a nationally accredited standards.

  • Legal assurance the accredited certification organization has ensured that the item that was successfully tested, and is identical to that which is being offered for sale.

  • Legal assurance that the successful test has resulted in a certification listing, which is considered public information, which sets out the tolerances and conditions of use for the certified product, to enable bounding, and thus compliance with the law.

  • Legal assurance that the manufacturer is being regularly audited by the Certification Organization, at unannounced intervals, to ensure the maintenance of the original process standard that was employed in the manufacture of the test specimen that passed the test, and that if the manufacturer should fail an audit, all product certification, including labels of stock on hand, on construction sites, with end-user customers and on distributor store shelves, shall be immediately removed, and all stakeholders will be informed that the de-listed product certification is no longer eligible for use in bounding. 



Quality Assurance

The Legal

Relationship Between

Certifier & Client



Product certification and product qualification is the cornerstone of all bounding for Certification Marks, and the process of certifying that a specific product has passed performance and quality assurance tests or qualification requirements stipulated in regulations and Nationally Accredited Test Standards, and that a product complies with a set of regulations governing quality and/or minimum performance requirements.


On the part of the certifier, in this case, the Glycemic Research Institute® (GRI), is certifying that a product has passed all Clinical Protocols established to use the Glycemic Research Institute® Certification Marks on a label and/or product marketing materials, including websites.


For products that pass the strict Clinical Protocol, the Glycemic Research Institute® allows the use the GRI Mark on the product label, thus indicating legal eligibility of the product for use in bounding, and certifies the origin, material, mode of manufacture of products, mode of performance of services, quality, and accuracy of other characteristics of the product.


Products, once certified, may be endorsed with the Authorized Certification Mark and may be eligible to display said Certification Mark, under the direction and guidelines of the Glycemic Research Institute®.


Trademarks vs 
Certification Marks

Trademarks are vastly different from Certification Marks. Trademarks are issued to individuals and companies and represent a word (s) or logo used by that entity. 


Certification Marks are difficult to register, and are only issued by the government to companies that are Nationally Accredited Testing and Certification Organizations.


It is difficult, lengthy, and expensive to obtain a Certification Mark from the government, as the organization applying for said Mark must prove worthiness on many different levels of competence, expertise, and good standing in the community.


Companies that are legally issued a Certification Mark must follow strict government guidelines in order to obtain, maintain and continue to use said Marks.


Example of Valid Certification Marks


The main purpose of government Certification Mark regulations is to protect consumers against misleading practices. 


Some of the more commonly seen Certification Marks are:

Underwriters Laboratories holds a service mark on the phrase "UL Listed," and allows manufacturers of electrical and other safety equipment to use the UL mark only if they are under follow-up agreement by UL. This lets consumers identify products that meet quality criteria set by a company other than the manufacturer.














The Bureau Veritas Certification Mark, used to indicate the Sea-Worthiness of Ships.







(U in a full circle), the hechsher of the Orthodox Union.


NanoBot and 
Red Blood Cells


Glycemic Research Institute has been conducting Human Clinical In Vivo Trials in the field of diabetes for the past 23 years. This picture represents Nanotechnology in diabetes research.

December 2007
Research Stands Up 
To Intense 

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2008 Department of Defense BUYERS GUIDE
Authorized 2008 Supplier/Vendor: 
Listing ID:

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